OCD Breakthrough: Brain Signal for Compulsions Identified
Groundbreaking 2026 research identifies low-gamma brain signal in right anteromedial orbitofrontal cortex as a real-time biomarker for OCD compulsions. Targeted DBS suppresses it rapidly—paving way for closed-loop therapies. **Human Lab Journal** **Volume 12, Issue 2 | February 2026** **Neuroscience & Neuromodulation Section** ### Brain Signal Linked to OCD Compulsions Identified **High-frequency activity in the right anteromedial orbitofrontal cortex emerges as a consistent neural marker—and a treatable target** **Summary** Researchers at the Perelman School of Medicine at the University of Pennsylvania have identified a distinct electrophysiological signature of compulsive behavior in people with obsessive-compulsive disorder (OCD). In a study published this month in *Cell*, elevated low-gamma power in the right anteromedial orbitofrontal cortex (amOFC) was found to rise reliably during symptom provocation and to drop sharply ...
