Brain on fire? Learn the signs of encephalitis, how it’s linked to mental health, and what recent research says about viruses like COVID-19 and brain health.

 When the Brain Is on Fire: What You Need to Know About Encephalitis and Brain Inflammation



When the Brain is on Fire: Understanding Encephalitis and Its Surprising Causes

By [Zahra Waleed]

Tags: #BrainHealth #Neuroscience #MentalHealth #Encephalitis #Neuroinflammation #Wellness


What If Your Brain Got Inflamed—Literally?

Imagine waking up confused, feverish, and struggling to remember where you are. You feel like you’re in a dream—or worse, a nightmare. For some people, this is the terrifying reality of encephalitis, also known as brain inflammation. It sounds like something from a medical drama, but it’s a very real and often overlooked neurological emergency.

So, what’s really going on when the brain is inflamed? And how can something like a virus—or even your own immune system—set off this internal wildfire?

Let’s break it down in plain English (with a bit of neuroscience flair).


What Is Encephalitis?

Encephalitis is an inflammation of the brain tissue. It’s not just a headache or mental fog—it’s a potentially life-threatening condition that affects brain function and can leave lasting cognitive or emotional effects.

Common Symptoms Include:

  • Fever

  • Headache

  • Seizures

  • Confusion or disorientation

  • Sensory disturbances

  • Weakness or paralysis

  • In severe cases, coma

It can affect anyone, but children, older adults, and people with weakened immune systems are more at risk.




What Causes Brain Inflammation?

Encephalitis has two main sources: infectious and autoimmune.

1. Infectious Encephalitis

Most often caused by viruses, including:

  • Herpes Simplex Virus (HSV)

  • West Nile Virus

  • Varicella Zoster (chickenpox/shingles)

  • COVID-19 (yes, really—more on this below)

These viruses can cross the blood-brain barrier, triggering a serious immune response that inflames brain tissue.

2. Autoimmune Encephalitis

Sometimes, your own immune system turns against your brain. One of the most recognized forms is anti-NMDA receptor encephalitis, which gained fame from the memoir and Netflix movie Brain on Fire by Susannah Cahalan.

In autoimmune encephalitis, the body mistakenly attacks healthy brain cells, leading to psychiatric symptoms, seizures, and cognitive decline.


Encephalitis & Mental Health: More Connected Than You Think

Here’s the twist: encephalitis doesn’t always look “physical.” Many patients first present with psychiatric symptoms like anxiety, hallucinations, paranoia, or depression. Misdiagnosis is common—some are mistakenly treated for psychosis or bipolar disorder before the root cause is found.

Recent studies have even suggested that neuroinflammation may be linked to depression and schizophrenia, though not necessarily full-blown encephalitis. (NIH Study, 2023)


The COVID-19 Link: A New Era of Brain Inflammation

In the post-pandemic world, researchers are uncovering an unsettling truth: COVID-19 can increase the risk of encephalitis and other neurological issues, even in mild or asymptomatic cases.

A study published in Nature Reviews Neurology (2024) highlights how SARS-CoV-2 can trigger prolonged inflammation in the brain, potentially leading to "brain fog," memory issues, and neurodegeneration. (Read full study)


How Is Encephalitis Diagnosed?

It typically involves:

  • MRI or CT scan of the brain

  • Lumbar puncture (spinal tap) to analyze cerebrospinal fluid

  • Blood tests to identify infections or autoimmune markers

  • EEG to monitor brain activity


Can It Be Treated?

Yes, but early diagnosis is crucial.

Treatments may include:

  • Antiviral medications (for viral encephalitis)

  • Immunotherapy or steroids (for autoimmune types)

  • Seizure control medications

  • Supportive therapies: rehab, speech therapy, psychotherapy

Recovery can take weeks to months—and for some, cognitive challenges may linger.


Stories of Survival: Real-Life Resilience

Remember Susannah Cahalan? Her journey through autoimmune encephalitis was misdiagnosed as a psychiatric breakdown before a spinal tap revealed the truth. Her recovery, documented in Brain on Fire, helped raise awareness of this underdiagnosed condition.

You can check out her full story here: Susannah Cahalan’s TED Talk


Brain Health Is Whole-Body Health

Encephalitis is a striking reminder that mental and physical health are deeply interconnected. That’s why it’s vital to pay attention to strange symptoms—especially when they affect your mood, memory, or thinking.

If something feels “off,” trust your instincts and seek help. It could save your brain—and your life.


Resources & Where to Learn More

Also, check out my recent article on How Long COVID Is Changing Our Understanding of the Brain


Final Thoughts

The brain is delicate, powerful, and surprisingly vulnerable. Encephalitis might be rare, but it's more common than we think—and more treatable than it used to be. The key? Awareness, early action, and a little help from science.

Stay curious. Stay safe. And always listen to what your brain is trying to tell you.


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